Start of Pivotal Phase III trial for Lutathera® in cancer patients with progressive midgut carcinoid

Advanced Accelerator Applications (AAA) announces the initiation of an international Phase III clinical trial evaluating the effect of Lutathera in patients with inoperable progressive midgut carcinoid. The study will be conducted at multiple centres in Europe and North America. The first European patient was enrolled on July 20th 2012 in Madrid, Spain. The FDA approved the trial on September 10th. The study, known as NETTER-1, is a Phase III, international, multi-center, randomised, comparator-controlled, parallel-group study evaluating the efficacy and safety of Lutathera compared to Novartis’ Sandostatin LAR. Phase II results in progressive midgut carcinoid showed Progression-Free Survival of more than 44 months compared to the reported 14.6 months of Novartis’ Sandostatin LAR.