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FDG
[18F] 2-Fluoro-2-Deoxy-D-glucose (hereinafter FDG) is a glucose analog with replacement of the oxygen in C-2 position with 18-fluorine. It has become widely used in nuclear medicine for diagnostic studies using a Positron Emission Tomography (PET) body scanning technique.
Because of the short half-life of the 18F isotope (110 min), this product must be produced in relatively large quantities to allow for decay during delivery to the patient from a manufacturing facility.
The preferred method of producing the 18F isotope is by bombarding water enriched with the 18O isotope using high-energy protons from a cyclotron. FDG radiopharmaceutical formulation must pass multiple quality control tests before it is used for any patient injection.
