Publications scientifiques & présentations

Clinical History of the Theranostic Radionuclide Approach to Neuroendocrine Tumors and Other Types of Cancer: Historical Review Based on an Interview of Eric P. Krenning by Rachel Levine

Levine R, Krenning EP. J Nucl Med (2017) volume 58, 3S-9S

Abstract

Peptide receptor radionuclide therapy of gastroenteropancreatic neuroendocrine tumors (GEP-NETs): From literature to practice

Bournaud C, Kelly A, Hindié E, Tenenbaum F, Faivre-Chauvet A, Courbon F, Taïeb D, Dierickx LO, Coriat R, Ansquer C. Med Nuc (2017) volume 41, pp 42-54.

Abstract

Phase 3 Trial of 177Lu-Dotatate for Midgut Neuroendocrine Tumors

Strosberg J, El-Haddad G, Wolin E, Hendifar A, Yao J, Chasen B, Mittra E, Kunz PL, Kulke MH, Jacene H, Bushnell D, O'Dorisio TM, Baum RP, Kulkarni HR, Caplin M, Lebtahi R, Hobday T, Delpassand E, Van Cutsem E, Benson A, Srirajaskanthan R, Pavel M, Mora J, Berlin J, Grande E, Reed N, Seregni E, Öberg K, Lopera Sierra M, Santoro P, Thevenet T, Erion JL, Ruszniewski P, Kwekkeboom D, Krenning E; NETTER-1 Trial Investigators. N Engl J Med. (2017) volume 376, pp 125-135.

Abstract

A Patient With Metastatic Sarcoma was Successfully Treated With Radiolabeled Somatostatin Analogs

Crespo-Jara A, González Manzano R, Lopera Sierra M, Redal Peña MC, Antonio Brugarolas Masllorens A. Clin Nucl Med. (2016), volume 41, pp 705-707.

Abstract

SPECT/CT Imaging in a Rabbit Model of Emphysema Reveals Ongoing Apoptosis In Vivo

Goldklang MP, Tekabe Y, Zelonina T, Trischler J, Xiao R, Stearns K, Romanov A, Muzio V, Shiomi T, Johnson LL, D'Armiento JM. Am J Respir Cell Mol Biol. (2016), volume 55, pp 848-857.

Abstract

NETTER-1 Phase III: Progression-Free Survival, Radiographic Response, and Preliminary Overall Survival Results in Patients with Midgut Neuroendocrine Tumors Treated with 177-Lu-Dotatate

Strosberg J, Wolin E, Chasen B, Kulke M, Bushnell D, Caplin M, Baum RP, Kunz P, Hobday T, Hendifar A, Oberg K, Lopera Sierra M, Kwekkeboom D, Ruszniewski P, Krenning E. 2016 Gastrointestinal Cancers Symposium, January 21-23, 2016, San Francisco, CA, USA.

Abstract

Single photon emission computed tomography imaging of cerebral blood flow, blood-brain barrier disruption, and apoptosis time course after focal cerebral ischemia in rats

Garrigue P, Giacomino L, Bucci C, Muzio V, Filannino MA, Sabatier F, Dignat-George F, Pisano P, Guillet B. Int. J. Stroke. (2016), volume 1, pp 117-126.

Abstract

177-Lu-Dotatate significantly improves progression-free survival in patients with midgut neuroendocrine tumours: Results of the phase III NETTER-1 trial

Strosberg J, Wolin E, Chasen B, Kulke M, Bushnell D, Caplin M, Baum RP, Mittra E, Hobday T, Hendifar A, Oberg K, Lopera Sierra M, Ruszniewski P, Kwekkeboom D. 2016 European Cancer Congress (ECC 2015), September 25-29, 2015, Vienna, Austria.

Abstract

Preclinical Validation of 99mTc-Annexin A5-128 in Experimental Autoimmune Myocarditis and Infective Endocarditis: Comparison with 99mTc-HYNIC-Annexin A5

Benali K, Louedec L, Azzouna RB, Merceron O, Nassar P, Al Shoukr F, Petiet A, Barbato D, Michel JB, Sarda-Mantel L, Le Guludec D, Rouzet F. Mol. Imaging (2014), volume 13, pp 1-10.

Abstract

NETTER-1: First Pivotal Multicenter Phase III Study Evaluating 177Lu-DOTATATE in Midgut Neuroendocrine Tumors

Lopera Sierra M, Yao JC, Wolin EM, Bushnell DL, O’Dorisio TM, Santoro P, Chasen BA, Mittra ES, Krenning EP, Strosberg JR, Kwekkeboom DJ. 8th Annual NET Conference, October 10-11, 2014, Nashville, Tennessee.

Abstract

NETTER-1: First Pivotal Phase III Study Evaluating 177LU-DOTATATE in Midgut Neuroendocrine Tumours

Lopera Sierra M, Kwekkeboom D, Mariani MF, Bodei L, Santoro P, Krenning EP. 39th ESMO Congress, September 26-30, 2014, Madrid, Spain.

Abstract

Experimental verification of neutron phenomenology in lead and of transmutation by adiabatic resonance crossing in accelerator driven systems: A summary of the TARC project at CERN.

Revol JP, et al. Nucl Instr and Methods in Phys Research (2001), volume 463, pp 586-592.

Abstract

The working group on TRADE, Triga Accelerator Driven Experiment, "TRADE Final Feasibility Report"

Index & Summary

First results from the neutron facility (nTOF) at CERN.

Borcea A, Buono S, Cennini P, Dahlfors M, Dangendorf V, Ferrari A, Garcia-Munoz G, Kadi Y, Lacoste V, Nolte R, Radermacher E, Rubbia C, Saldana F, Vlachoudis V, Weierganz T, Zanini L. Appl Phys A (2002), volume 74, S55-57.

Adiabatic Resonance Crossing for Accelerator Production of Neutron-rich Activated Nanospheres for Brachytherapy.

15th international Symposium of Radiopharmaceutical Chemistry, August 10-14, 2003, Sydney, Australia. Buono S, Ber G, Dasse P, Fessi H, Kadi Y, Maciocco L, Mehier H, Zanini L. J Label Compd Radiopharm (2003), volume 46: S1-S403.

Abstract

Adiabatic Resonance Crossing for Accelerator Production of Neutron-rich Isotopes.

8th ICATPP Conference on Astroparticle, Particle, Space Physics, Detectors and Medical Physics Applications, October 6-10, 2003, Villa Erba, Como, Italy. Buono S, Ber G, Dasse P, Fessi H, Kadi Y, Maciocco L, Mehier H, Zanini L.

Abstract

"The TRADE Target Design and Development".

2003 ANS Annual Meeting “The Nuclear Technology Expansion - Unlimited Opportunities”, June 1-5, 2003, San Diego, California. Agostini P, Aiello A, Turroni P, Pisacane F, Monti S, Buono S, Maciocco L, Maloy S, Salvatores M, Lejeail Y.

Abstract

"The TRADE Solid Target System Design".

International Conference GLOBAL-November 16-20, 2003, New Orleans, Louisiana. Krakowiak-Aillaud C, Bergeron A, Kadi Y, Agostini P, Palomba M, Maciocco L, Struwe D, Chen H, Cheng X, Granget G, Lejeail Y, Turroni P, Monti S , Salvatores M.

Abstract

Results from the commissioning of the n_TOF spallation neutron source at CERN.

Borcea C, Cennini P, Dahlfors M, Ferrari A, Garcia-Munoz G, Haefner P, Herrera-Martinez A, Kadi Y, Lacoste V, Radermacher E, Saldana F, Vlachoudis V, Zanini L. Nucl Instr and Meth A (2003), volume 513, pp 524-537.

Abstract

Les médicaments radiopharmaceutiques fluorés.

Quelven I, Balard M, Monteil J, Tafani JAM. Actualités Pharmaceutiques Hospitalières (2005), numéro 4: pp 46-55.

Abstract

The TracerLab Maximum (Mx) is also a Flexible (Fx) tool.

16th International Symposium on Radiopharmaceutical Chemistry, Iowa City, Iowa, June 24-28, 2005. Tadino V, Kothari PJ, Le Bars D, Villeret G, Tesoriere G, Ignace G, Vallabhajosula S, Buono S.

Abstract Poster

Development of a target system for the production of ß- emitting radioisotopes with small-size cyclotrons.

11th Workshop on Targetry and Target Chemistry, Robinson College, University of Cambridge, United Kingdom, August 28-31, 2006. Buono S, Burgio N, Maciocco L, Rocca R.

Abstract

A computational study of salt diffusion and heat extraction in solar pond plants.

Angeli C, Leonardi E, Maciocco L. Solar Energy (2006), volume 80, pp 1498-1508.

Abstract

Silicon Photomultipliers and their bio-medical applications.

Grigoriev E, Akindinov A, Breitenmoser M, Buono S, Charbon E, Niclass C, Desforges I, Rocca R. Nucl Instrum Methods Phys Res A (2007), volume 571, pp 130-133.

Abstract

Synthesis and biological evaluation in rat and cat of [18F]12ST05 as a potential 5-HT6 PET radioligand.

Tang S, Verdurand M, Joseph B, Lemoine L, Daoust A, Billard T, Fournet G, Le Bars D, Zimmer L. Nucl Med Biol (2007), volume 34, pp 995-1002.

Abstract

Brachytherapy: state of the art and possible improvements.

Buono S, Burgio N, Hamoudeh M, Fessi H, Hiltbrand E, Maciocco L, Mehier-Humbert S. Anticancer Agents Med Chem (2007), volume 7, pp 411-424.

Abstract

Holmium-loaded PLLA nanoparticles for intratumoral radiotherapy via the TMT technique: preparation, characterization, and stability evaluation after neutron irradiation.

Hamoudeh M, Fessi H, Salim H, Barbos D. Drug Dev Ind Pharm (2008), volume 34, pp 796-806.

Abstract

Automated radiosynthesis of the Pittsburg compound-B using a commercial synthesizer.

Verdurand M, Bort G, Tadino V, Bonnefoi F, Le Bars D, Zimmer L. Nucl Med Commun (2008), volume 29, pp 920-926.

Abstract

In vivo quantification of 5-HT1A-[18F]MPPF interactions in rats using the YAP-(S)PET scanner and a beta-microprobe.

Millet P, Moulin M, Bartoli A, Del Guerra A, Ginovart N, Lemoucheux L, Buono S, Fagret D, Charnay Y, Ibanez V. Neuroimage (2008), volume 41, pp 823-834.

Abstract

Fully automated [18F]fluorocholine synthesis in the TracerLab MX FDG Coincidence synthesizer.

Kryza D, Tadino V, Filannino MA, Villeret G, Lemoucheux L. Nucl Med Biol (2008), volume 35, pp 255-260.

Abstract

An accelerator-driven production of Mo-99 at CERN as a longterm solution to the current world crisis in diagnostic medical imaging.

Buono S. (2009).

White paper

EANM 2009, Annual Congress of the European Association of Nuclear Medicine, October 10-14, 2009, Barcelona, Spain. A cyclotron-driven neutron activator for the production of β- emitting radioisotopes for brachytherapy. 

Buono S, Maciocco L, Abbas K, Cotogno G, Simonelli F, Cydzik I, Gibson N, Holzwarth U, Burgio N, Mercurio G, Santagata A, Tagziria H, Billotey C, Taleb J.

Abstract Poster

EANM 2009, Annual Congress of the European Association of Nuclear Medicine, October 10-14, 2009, Barcelona, Spain. New modality of curietherapy with holmium oxide submicronic particles.

Taleb J, Mutelet B, Maccioco L, Kryza D, Humbert S, Tillement O, Hiltbrand E, Louise C, Janier MF, Roux S, Abbas K, Simonelli F, Perriat P, Billotey C.

Abstract Poster

Acute and chronic effects of citalopram on 5-HT1A receptor- labeling by [18F]MPPF and - coupling to receptors-G proteins.

Moulin-Sallanon M, Charnay Y, Ginovart N, Perret P, Lanfumey L, Hamon M, Hen R, Fagret D, Ibanez V, Millet P. Synapse (2009), volume 63, pp 106-116.

Abstract

[N-Methyl-11C]choline by on-column reaction: a study on [11C]CH3I incorporation and the residual amount of precursor in the product.

Bogni A, Crispu O, Fugazza L, Cucchi C, Laera L, Iwata R, Crippa F, Bombardieri E, Pascali C. J. Label Compd. Radiopharm (2010)

Abstract

A cyclotron-driven neutron activator for the production of β- emitting radioisotopes for brachytherapy.

Physics for Health in Europe Workshop (February 2-4, 2010 - Geneva, Switzerland) Buono S, Maciocco L, Burgio N, Santagata A, Abas K, Simonelli F.

Abstract

[18F]F15599, a novel 5-HT1A receptor agonist, as a radioligand for PET neuroimaging.

Lemoine L, Verdurand M, Vacher B, Blanc E, Le Bars D, Newman-Tancredi A, Zimmer L. Eur J Nucl Med Mol Imaging (2010), volume 37, pp 594-605.

Abstract

Looking for a 5-HT7 radiotracer for positron emission tomography.

Andriès J, Lemoine L, Mouchel-Blaisot A, Tang S, Verdurand M, Le Bars D, Zimmer L, Billard T. Bioorg Med Chem Lett. (2010), volume 20, pp 3730-3733.

Abstract

XT-ADS Windowless spallation target thermohydraulic design & experimental setup.

Class AG, Angeli D, Batta A, Dierckx M, Fellmoser F, Moreau V, Roelofs F, Schuurmans P, Van Tichelen K, Wetzel T, J. Nuclear Materials (2011), volume 415, pp 378-384.

Abstract

Synthesis and biological evaluation of potential 5-HT(7) receptor PET radiotracers.

Andries J, Lemoine L, Le Bars D, Zimmer L, Billard T, Eur J Med Chem. (2011), volume 46, pp 3455-3461.

Abstract

Radiolabelling of engineered nanoparticles for in vitro and in vivo tracing applications using cyclotron accelerators.

Gibson N, Holzwarth U, Abbas K, Simonelli F, Kozempel J, Cydzik I, Cotogno G, Bulgheroni A, Gilliland D, Ponti J, Franchini F, Marmorato P, Stamm H, Kreyling W, Wenk A, Semmler-Behnke M, Buono S, Maciocco L, Burgio N. Arch Toxicol. (2011), volume 85, pp 751-773.

Abstract

Comparison of 4 Radiolabeled Antagonists for Serotonin 5-HT7 Receptor Neuroimaging: Toward the First PET Radiotracer.

Lemoine L, Andries J, Le Bars D, Billard T, Zimmer L (2011), J Nucl Med, volume 52, pp 1811-1818.

Abstract

Effects of amyloid-beta peptides on the serotoninergic 5-HT(1A) receptors in the rat hippocampus.

Verdurand M, Berod A, Le Bars D, Zimmer L. Neurobiology of Aging (2011), volume 32, pp 103-114.

Abstract

Monte Carlo simulation and radiometric characterization of proton irradiated [18O]H2O for the treatment of the waste streams originated from [18F]FDG synthesis process.

Remetti R, Burgio NT, Maciocco L, Arcese M, M. Filannino A, Appl. Radiat. Isot. (2011), volume 69, pp 1046-51.

Abstract

Synthesis and Reactivity of a Bis-Sultone Cross-Linker for Peptide Conjugation and [18F]-Radiolabelling via Unusual “Double Click” Approach.

Priem T, Bouteiller C, Camporese D, Romieu A, Renard PY, Org. Biomol. Chem. (2012), volume 10, pp 1068-1078.

Abstract

A novel sulfonated prosthetic group for [18F]- radiolabelling and imparting water solubility of biomolecules and cyanine fluorophores

Priem T, Bouteiller C, Camporese D, Brune X, Hardouin J, Romieu A, Renard PY, Org. Biomol. Chem. (2013), volume 11, pp 469-479.

Abstract

Radiosynthesis and in vivo evaluation of fluorinated huprine derivates as PET radiotracers of acetylcholinesterase

Da Costa Branquinho E, Becker G, Bouteiller C, Jean L, Renard PY, Zimmer L. Nucl. Med. Biol. (2013), volume 40, pp 554-560.

Abstract

Study of inter- and intra-observer reproducibility in the interpretation of [18F]choline PET/CT examinations in patients suffering from biochemically recurrent prostate cancer following curative treatment

Pegard C, Gallazzini-Crépin C, Giai J, Dubreuil J, Caoduro C, Desruet MD, Roux J, Calizzano A, Fagret D, Lamesa C, Boulahdour H, Vuillez JP. EJNMMI Research 2014, 4:25

Abstract

Experimental verification of neutron phenomenology in lead and of transmutation by adiabatic resonance crossing in accelerator driven systems: A summary of the TARC project at CERN.

Revol JP, et al. Nucl Instr and Methods in Phys Research (2001), volume 463, pp 586-592.

Abstract

Peptide receptor radionuclide therapy with 177Lu-DOTATATE for patients with somatostatin receptor-expressing neuroendocrine tumors: the first US phase 2 experience

Delpassand ES1, Samarghandi A, Zamanian S, Wolin EM, Hamiditabar M, Espenan GD, Erion JL, O'Dorisio TM, Kvols LK, Simon J, Wolfangel R, Camp A, Krenning EP, Mojtahedi A. Pancreas (2014), volume 43, pp 518-525.

Abstract